瓦赫寧根大學2024/11/29： 悉達多·德斯潘德 和馬斯垂克大學的 英格麗·迪克格拉夫 團隊 在 Nature Chemistry 期刊上發表了一篇名爲：蜱膠粘劑中富甘氨酸蛋白的相分離與老化的論文. Phase separation and ageing of glycine-rich protein from tick adhesive.
BIOADHESIVES
How ticks stick
Michael A. Funk
Insect parasites have invented ingenious ways of attaching to and manipulating their
hosts through salivary secretions. In addition to grasping with their mouthparts, ticks exude a proteinaceous cement that helps them stay attached over several days. Ganar et al. used in vitro peptide synthesis to study a glycine-rich protein from the deer tick Ixodes scapularis. They show that this protein forms liquid condensates and transitions to a gel-like adhesive over time. This mechanism may be common to other glycine-rich peptides in tick saliva or in other bioadhesives produced by invertebrates.
該研究：硬蜱Ixodes scapularis唾液中的甘氨酸豐富蛋白（GRP）通過液–液相分離（LLPS）形成生物分子凝聚體的機制，發現GRP在鹽誘導和蒸發條件下發生相分離並通過陽離子–π和π–π相互作用驅動該過程。研究表明，這些凝聚體隨着時間由液態轉變爲固態凝膠，表現出與蜱的水泥錐類似的粘附特性。此外，實驗提供了自然蜱唾液中存在蛋白質富集凝聚體的證據。該研究爲理解蜱的生物粘附機制、開發蜱控制策略以及生物醫學應用（如組織密封劑）提供了科學基礎 。
但以理實驗室目前已有5篇生物黏著劑科研獲獎同時申請專利，此篇顯示天然黏著劑仍有許多未開發，儘管GRPs被認爲提供了水泥錐的強度和穩定性，其具體機制仍未解明。加油。
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